No, the I-485 is filed only once you are already in the US on the K-3 visa, assuming the I-130 is not processed before that and you enter the US already as a permanent resident.
Your spouse will have to file the I-130 first and once the receipt from that petition is obtained, file the I-129F along with all the other supporting documentation.
Please let me know if you have any additional questions or if I may be of further assistance to you in this matter.
Thanks,
Lana
Immigration Attorney
Admitted to practice in CA, AZ, IN and OH