drug charge gone wrong

What is the name of your state?georgia
if arrested for possession of meth (small amount, .6 gram)
if you are in a leased vehicle can it be seized, especially with
a large balance on the lease?

Yes it can be seized and guess what? You're still going to be paying for it once you get out of jail.

About 12 years ago I bought an almost new Pontiac Trans Am at a border patrol siezure auction. The car had only 433 miles on it. Yep, a druggie loser had his car siezed only 3 days after buying it and he still owed over $14,000 on it. The guy lost the car over a small butt of a marijuana cigarette found in the ashtray.

Talk to a lawyer, seizure laws differ per state and change with the wind.