I do know that leasehold title insurance policies are bought in a number of situations for commercial leases. Especially if significant-tenant paid improvements or customized made-to-fit equipment will be installed. This protects the leasee in the event of a title failure affecting the leasor's intrerest, or that the leasor was not acting with proper authority. THis also discloses deed restrictions and easements which could impact intended use
AS for opening escrow, hopefully a CA atty will answer that, as we don't even "open escrow" for a commercial sale in my market, otrher than to hold earnest money or to hold environmental remediation funds.