The ex wife has been paying on the debt. She acknowledges her part.
How recently? I assume she has missed payments or not made payments in the amounts required, hence the collection letters.
... His ex is actively paying her half.
How actively? Has she only paid “half” of the payments due? Did she expect or assume her ex, the blind man, was paying the other half? Was the man ordered as part of a divorce agreement to continue paying half of what was owed?
It appears that the man needs to go over all relevant facts with an attorney in his area. It does not appear that you have the necessary information to assist us in determining his obligation to pay the debt.
I suspect that his signature alone on the loan acquired in 2008 has legally bound him to the terms of the agreement, and that his blindness and chemotherapy treatments are not going to relieve him of that obligation. But I could be wrong.